Review of Clinical Trials
A selection of peer-reviewed studies on St. John's Wort for depression. These are the sources behind much of the comparison with prescription antidepressants.
- Szegedi, A., Kohnen, R., Dienel, A. & Kieser, M. (2005). Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double-blind non-inferiority trial versus paroxetine. British Medical Journal, 330(7974):759.
- Fava, M., Alpert, J., Nierenberg, A. A., Mischoulon, D., Otto, M. W., Zajecka, J., Murck, H. & Rosenbaum, J. F. (2005). A double-blind, randomized trial of St. John's wort, fluoxetine, and placebo in major depressive disorder. Journal of Clinical Psychopharmacology, 25(5):441–447.
- Seelinger, G. & Mannel, M. (2007). Drug treatment in juvenile depression? Is St. John's wort a safe and effective alternative? Journal of Child and Adolescent Mental Health, 12(3):143–149.
- Fegert, J. M., Kolch, J., Zito, J. M., Glaeske, G. & Jahnsen, K. (2006). Antidepressant use in children and adolescents in Germany. Journal of Child and Adolescent Psychopharmacology, 16(1–2):197–206.
- Friede, M., Henneicke von Zepelin, H. H. & Freudenstein, J. (2001). Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort. Pharmacopsychiatry, 31(1):S38–41.