Review of Clinical Trials

Szegedi, A., Kohnen, R., Dienel, A. & Kieser, M. (2005). Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John’s wort): Randomised controlled double blind non-inferiority trial versus paroxetine. British Medical Journal, 330(7974):759.

Fava, M., Alpert, J., Nierenberg, A.A., Mischoulon, D., Otto, M.W., Zajecka, J., Murck, H. & Rosenbaum, J.F. (2005). A double-blind, randomized trial of St. John’s wort, fluoxetine, and placebo in major depressive disorder. Journal of Clinical Psychopharmacology, 25(5):441-447.

Seelinger, G. & Mannel, M. (2007). Drug treatment in juvenile depression? Is St. John’s wort a safe and effective alternative? Journal of Child and Adolescent Mental Health, 12(3):143-149.

Fegert, J.M., Kolch, J., Zito, J.M., Glaeske, G. & Jahnsen, K. (2006). Antidepressant use in children and adolescents in Germany. Journal of Child and Adolescent Psychopharmacology, 16(1-2):197-206.

Friede, M., Henneicke von Zepelin, H.H. & Fraudenstein, J. (2001). Differential theory of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John’s wort. Pharmacopsychiatry, 31(1): S38-41.